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In reference to the sentence in that section: "Increased extracellular potassium levels result in depolarization of the membrane potentials of cells due to the increase in the equilibrium potential of potassium."
The K+ equilibrium potential (EK) becomes LESS negative with hyperkalemia (as can be calculated with the Nernst equation). The phrasing "increase in" can be confusing when dealing with negative numbers: it could be interpreted as 'increase' to a higher number (say from -90 to -100 where 100 is higher than 90) or as an 'increase' to a less negative number (say from -90 to -80). I think better wording would be to rewrite this sentence as: "Increased extracellular potassium levels result in depolarization of the membrane potentials of cells due to the equilibrium potential of potassium becoming less negative."
Thoughts?
What about calculating TTKG to aid in the differential diagnosis? Cybergoth 12:18, 27 August 2005 (UTC)Reply
Yes, that would be useful. Here is an online calculator. JFW | T@lk 23:08, 27 August 2005 (UTC)Reply
Deleted "Liddles Syndrome" & "Pseudohyperaldosteronism" from the Differential Diagnosis, since those are associated with HYPOkalemia. 129.22.127.147 02:51, 10 March 2006
I like that "lethal injection" is listed under "causes include:" :-) Mbarbier 17:48, 8 November 2007 (UTC)Reply
Increased extracellular potassium will cause hyperpolarization and not depolarization of the cell membrane. dont you agree?
Disagree: Imagine a typical cell which has a membrane voltage determined predominately by conductance through potassium channels. The point of equilibrium (where the membrane potential will equilibrate) is the Nernst potential for K, which equals -60mV*Log([K]i/[K]o). As [K]o rises, the membrane will equilibrate at a less negative potential. Hence, the cell will be depolarized in the setting of hyperkalemia. DanLevy 04:53, 10 June 2006 (UTC)Reply
Will delete comment by user 85.167.25.246 regarding Hyperkalemia causing acidosis. True that cardiac arrest, or weakness of diaphragmatic muscles could lead to hypoxia/ischemia that would cause acidosis, but I think that these would be extreme examples, and the statement is otherwise misleading. Dan Levy 03:26, 12 December 2006 (UTC)Reply
Jan 11th, 2007
Changed the phrase: Potassium is the most important intracellular cation and participates in many cellular processes to Potassium is an important intracellular cation and participates in many cellular processes.
I don't think you can establish that K+ is the most important intracellular cation, considering the important of Na+ and Ca2+.
I deleted the phrase: "It can be avoided by using plasma from anticoagulated blood samples, as this will reduce the destruction of cells and platelets during the clotting process." because I think that it was misleading. It was located right after mentioning the familial pseudohyperkalemias. In fact, in ref 3 (Blood, 1999) the heparinized blood that incubates for a few hrs shows increased serum [K] over time. But I think that the statement might apply for thrombocytosis and perhaps it should simply be moved to a different position in the paragraph? I assume that the best strategy for any suspected case of pseudohyperkalemia would be to spin anticoagulated blood immediately and measure the K from the plasma. I know that plasma K is always a bit lower than serum K, but would user 205.160.195.36 be able to offer a reference that anticoagulation would specifically be helpful when pseudohyperkalemia is suspected? Dan Levy 22:59, 19 June 2007 (UTC)Reply
Since the death penalty is contrary to international law and human rights as generally understood, I find it inappropriate to mention its methodology in the context of an article on a medical subject. I would urge the deletion of the relevant paragraph.83.65.178.206 (talk) 10:37, 30 October 2008 (UTC)Reply
I agree with user user:Mikael Häggström that it makes more sense to split the TREATMENT section into acute mgmt and prevention. But I'm not sure what should be done with Kayexalate. In some patients, it is used chronically to reduce the risk of a hyperkalemic episode, but it also used to remove K from the body in a patient with a mild-to-mod hyperkalemia, such as in the 5.5-6.2 mEq/L range, in a patient who might not otherwise need dialysis. So wouldn't this *also* be acute treatment? Suggestions, anyone? Dan Levy (talk) 14:59, 6 January 2009 (UTC).Reply
Tomato paste is the most-concentrated dietary source of potassium. —Preceding unsigned comment added by 66.167.61.132 (talk) 22:39, 16 April 2009 (UTC)Reply
What would be "massive doses of oral KCl supplements", also in terms of tomato paste (twice concentrated)? --Ayacop (talk) 18:10, 1 June 2009 (UTC)Reply
Elliott MJ, Ronksley PE, Clase CM, Ahmed SB, Hemmelgarn BR (2010). "Management of patients with acute hyperkalemia". CMAJ. 182 (15): 1631–5. doi:10.1503/cmaj.100461. PMID 20855477. {{cite journal}}
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Doc James (talk · contribs · email) 20:51, 28 November 2010 (UTC)Reply
doi:10.1002/14651858.CD003235.pub2 - Cochrane review of emergency treatment.
doi:10.1136/bmj.b4114 - BMJ review 2009. JFW | T@lk 14:38, 21 September 2012 (UTC)Reply
The following resources may be useful in enriching this article:
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suggested) (help)DiptanshuTalk 14:09, 24 June 2013 (UTC)Reply
WP:MEDRS-compatible sources are available (I've posted a few above over the last few months) but we're not using them... JFW | T@lk 11:51, 19 January 2014 (UTC)Reply
I don't see the connection of this sentence to Hyperkalemia. Assuming that there is one, perhaps someone could make it more obvious?
"The combination of abdominal pain, hypoglycemia, and hyperpigmentation—often in the context of other autoimmune disorders—may indicate Addison's disease,[12] which is a medical emergency."
Rick.Wicks (talk) 10:21, 4 October 2016 (UTC)Reply
Social media has been promoting cream of tartar, a cooking ingredient with the chemical name potassium bitartrate as a cure for several things including Migraines, losing weight etc. "Ingesting extremely high quantities of the chemical is not advisable as it can result in life-threatening cases of hyperkalemia, which is the abnormally high concentration of potassium in the blood."
To keep his brief I just quote Snopes - probably not good enough reference for here - but it mentions the current obsession. I leave to others to consider... https://www.snopes.com/fact-check/cream-of-tartar-migraine-headaches/ 60.242.247.177 (talk) 21:11, 19 December 2018 (UTC)Reply
I understand fast acting insulin (Novorapid to be precise) is used to treat acute hyperkalemia. Especially in a clinical setting where the cause is due to surgery or other treatment. The patient is given an IV solution of Novorapid with glucose (the avoid hypoglycemia due to the extra insulin). This is done mainly where blood- or other fluid losses- are the cause of the hyperkalemia, not when there is a systemic problem. Should these two things be included in the article? Fast acting insulin as a treatment and blood cq fluid loss as a cause?
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