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Tiamulin





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Tiamulin (previously thiamutilin) is a pleuromutilin antibiotic drug that is used in veterinary medicine particularly for pigs and poultry.[1][2]

Tiamulin
Clinical data
Trade namesDynamutilin, others
Routes of
administration		Oral
ATCvet code
Legal status
Legal status
  • Veterinary use only
Identifiers

  • (4R,5S,6S,8R,9aR,10R)-5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl {[2-(diethylamino)ethyl]sulfanyl}acetate

CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.054.145 Edit this at Wikidata
Chemical and physical data
FormulaC28H47NO4S
Molar mass493.75 g·mol−1
3D model (JSmol)

  • CCN(CC)CCSCC(=O)O[C@@H]1C[C@@]([C@H]([C@@H]([C@@]23CC[C@H]([C@@]1([C@@H]2C(=O)CC3)C)C)C)O)(C)C=C

  • InChI=1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1 ☒N

  • Key:UURAUHCOJAIIRQ-QGLSALSOSA-N ☒N

 ☒NcheckY (what is this?)  (verify)

Tiamulin is a diterpene antimicrobial with a pleuromutilin chemical structure similar to that of valnemulin.[3]

References

edit
  1. ^ "Tiamulin in Veterinary Medicine". HACCP. Archived from the original on 2009-06-10.
  • ^ Long KS, Hansen LH, Jakobsen L, Vester B (April 2006). "Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center". Antimicrobial Agents and Chemotherapy. 50 (4): 1458–62. doi:10.1128/AAC.50.4.1458-1462.2006. PMC 1426994. PMID 16569865.
  • ^ "Tiamulin Summary Report" (PDF). EMEA.


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    Last edited on 24 June 2024, at 08:02  





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    ●This page was last edited on 24 June 2024, at 08:02 (UTC).
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