Transphosphorylation

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Transphosphorylation is a chemical reaction in which a phosphate group or a phosphono group is transferred between a substrate and a receptor.^[1] There are various phosphate esters in living body including nucleic acid, and phosphorylation reaction related to their synthesis and interconversion is the basis of biochemical reaction.^[2]^[3] In most cases, ATP is the substrate of the phosphate group as a substrate and the enzyme that catalyzes these reactions is referred to as kinase.^[4]

References

^ Ardecky, Robert J.; Bobkova, Ekaterina V.; Kiffer-Moreira, Tina; Brown, Brock; Ganji, Santhi; Zou, Jiwen; Pass, Ian; Narisawa, Sonoko; Iano, Flávia Godoy; Rosenstein, Craig; Cheltsov, Anton; Rascon, Justin; Hedrick, Michael; Gasior, Carlton; Forster, Anita (2014-02-01). "Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes". Bioorganic & Medicinal Chemistry Letters. 24 (3): 1000–1004. doi:10.1016/j.bmcl.2013.12.043. ISSN 1464-3405. PMC 3943210. PMID 24412070.

^ Wang, Qian; Kang, Yoon-Suk; Alowaifeer, Abdullah; Shi, Kaixiang; Fan, Xia; Wang, Lu; Jetter, Jonathan; Bothner, Brian; Wang, Gejiao; McDermott, Timothy R. (2018-05-25). "Phosphate starvation response controls genes required to synthesize the phosphate analog arsenate". Environmental Microbiology. 20 (5): 1782–1793. doi:10.1111/1462-2920.14108. ISSN 1462-2920. PMID 29575522. S2CID 4700039.

^ Tasnádi, Gábor; Zechner, Michaela; Hall, Mélanie; Baldenius, Kai; Ditrich, Klaus; Faber, Kurt (2017-10-06). "Investigation of acid phosphatase variants for the synthesis of phosphate monoesters". Biotechnology and Bioengineering. 114 (10): 2187–2195. doi:10.1002/bit.26352. ISSN 1097-0290. PMID 28600898. S2CID 25563592.

^ Wan, Paul T. C.; Garnett, Mathew J.; Roe, S. Mark; Lee, Sharlene; Niculescu-Duvaz, Dan; Good, Valerie M.; Jones, C. Michael; Marshall, Christopher J.; Springer, Caroline J.; Barford, David; Marais, Richard; Cancer Genome Project (2004-03-19). "Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF". Cell. 116 (6): 855–867. doi:10.1016/s0092-8674(04)00215-6. ISSN 0092-8674. PMID 15035987.

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