Born in Stuttgart, Eipperle studied at the Musikhochschule in her native Stuttgart, and made her stage debut in Wiesbaden, in 1930. She sang in Nuremberg (1930–34), Brunswick (1934–37), Munich (1938–44), Cologne (1945–51), and Stuttgart from 1951 onwards. She also appeared at the Salzburg Festival in 1942.
She made guest appearances in Vienna, Milan, Barcelona, Lisbon, Brussels, Monte Carlo, Paris and London.
Her repertory included Countess Almaviva, Pamina, Agathe, Elisabeth, Elsa, Eva, Marschallin, Arabella, Empress/Kaiserin (Die Frau ohne Schatten), but she was also admired as Desdemona in Verdi's Otello, Mimi in La boheme, and Cio-Cio-San in Madama Butterfly.