 | |
| Legal status | |
|---|---|
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C23H29N3O2 |
| Molar mass | 379.504 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
1P-LSD (1-propanoyl-lysergic acid diethylamide) is a psychedelic drug of the lysergamide class that is a derivative and functional analogueofLSD and a homologueofALD-52. It originated in 2015 when it appeared a designer drug sold online.[1][2][3][4][5][6] It modifies the LSD molecule by adding a propionyl group to the nitrogen molecule of LSD's indole group.[7][8]
Like ALD-52, 1P-LSD is believed to act as prodrug for LSD via hydrolysis of the propionyl group. When 1P-LSD is incubated in human serum,[9] administered intravenously to rats,[10] or administered either orally or intravenously to human subjects,[11] high levels of LSD and relatively low levels of 1P-LSD are quickly detected, demonstrating that 1P-LSD is rapidly hydrolyzed into LSD in vivo following ingestion. Indeed, following intravenous administration in humans 1P-LSD is detectable in serum for no longer than 4 hours, after which it is completely converted to LSD.[11] These findings are supported by the similar duration and behavioral effects of 1P-LSD and LSD in both animal and human experiments.[9][11]
The subjective effects of 1P-LSD are not well defined in the scientific literature, although they are generally thought to be comparable to that of LSD.[12] In a 2020 study, the qualitative effects of 1P-LSD and LSD were similar when measured using visual analog scales.
As of 2015, 1P-LSD is unscheduled in the United States and Canada, but may be considered illegal if sold or used for human consumption as a structural analog of LSD under the Federal Analogue Act in the US.[9] 1P-LSD is a prohibited or controlled substance in Australia, France,[13] Finland,[14] Denmark,[15] Germany,[16] Estonia,[17] Japan,[18] Latvia,[19] Norway,[20] Romania,[21] Sweden,[22] Switzerland,[23] United Kingdom,[24] Italy,[citation needed] Singapore,[25] the Czech Republic,[26] and Croatia.[27] 1P-LSD has been illegal in Russia since 2017 as an LSD derivative.[28]
|
| |
|---|---|
| Lysergic acid derivatives |
|
| Psychedelic lysergamides |
|
| Clavines |
|
| Other ergolines |
|
| Natural sources |
Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui) |
