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Names | |
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Preferred IUPAC name
4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol | |
Other names
T1AM | |
Identifiers | |
3D model (JSmol) |
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ChemSpider |
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ECHA InfoCard | 100.211.501 ![]() |
PubChem CID |
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CompTox Dashboard (EPA) |
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Properties | |
C14H14INO2 | |
Molar mass | 355.17 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
3-Iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor.[1][2]T1AM is the most potent endogenous TAAR1 agonist yet discovered.[3] Activation of TAAR1 by T1AM results in the production of large amounts of cAMP. This effect is coupled with decreased body temperature and cardiac output.[4]Wuet al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.[3]
T1AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.[5]
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Tyrosine / iodotyrosine |
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Thyronine / iodothyronine |
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Thyronamine / iodothyronamine |
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Iodothyroacetate / iodothyroacetic acid |
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TAAR1 |
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TAAR2 |
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TAAR5 |
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† References for all endogenous human TAAR1 ligands are provided at List of trace amines
‡ References for synthetic TAAR1 agonists can be found at TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 agonists and inverse agonists, see TAAR for references.
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Phenethylamines |
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Amphetamines |
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Phentermines |
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Cathinones |
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Phenylisobutylamines |
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Phenylalkylpyrrolidines |
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Catecholamines (and close relatives) |
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Miscellaneous |
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