34βE12, often written as 34betaE12 and also known as CK34βE12 and keratin 903 (CK903), is an antibody specific for high molecular weight cytokeratins 1, 5, 10 and 14.[1][2]
It is sometimes, less precisely, referred to as high-molecular weight keratin (HMWK) and high-molecular weight cytokeratin (HMWCK).
It is used to stain basal cellsinprostatic glands; loss of basal cells is seen in prostate adenocarcinoma (the most common form of prostate cancer).
It can be used to differentiate in situ cancers of the breast; lobular carcinoma in situ (LCIS) exhibits perinuclear staining with 34βE12. Ductal carcinoma in situ (DCIS) does not stain for 34βE12.[2]
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