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Contents

   



(Top)
  


1 See also  




2 References  













4-PPBP






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From Wikipedia, the free encyclopedia
  

4-PPBP
Skeletal formula of 4-PPBP
Ball-and-stick model of the 4-PPBP molecule
Names
Preferred IUPAC name

4-Phenyl-1-(4-phenylbutyl)piperidine

Identifiers

CAS Number

3D model (JSmol)
  • Interactive image
    • ChEMBL
    ChemSpider
    MeSH 4-phenyl-1-(4-phenylbutyl)piperidine

    PubChem CID
    UNII

    CompTox Dashboard (EPA)

    • InChI=1S/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2 checkY

      Key: HQGDPZPNAXRCSA-UHFFFAOYSA-N checkY

    • InChI=1/C21H27N/c1-3-9-19(10-4-1)11-7-8-16-22-17-14-21(15-18-22)20-12-5-2-6-13-20/h1-6,9-10,12-13,21H,7-8,11,14-18H2

      Key: HQGDPZPNAXRCSA-UHFFFAOYAV

    • C1CN(CCC1C2=CC=CC=C2)CCCCC3=CC=CC=C3

    • c1ccccc1C3CCN(CCCCc2ccccc2)CC3

    Properties

    Chemical formula

    		 C21H27N
    Molar mass 293.446 g/mol

    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    ☒N verify (what is checkY☒N ?)

    Infobox references

    4-PPBP is a neuroprotective cyclic amine which binds to sigma receptors.[1]

    4-PPBP decreases neuronal nitric oxide synthase (nNOS) activity and ischemia-evoked nitric oxide (NO) production. 4-PPBP provides neuroprotection; this involves the prevention of ischemia-induced intracellular Ca2+ dysregulation.[2] 4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB). Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB.[3]

    See also[edit]

    References[edit]

    1. ^ Yang S, Bhardwaj A, Cheng J, Alkayed NJ, Hurn PD, Kirsch JR (May 2007). "Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2". Anesthesia and Analgesia. 104 (5): 1179–84, tables of contents. doi:10.1213/01.ane.0000260267.71185.73. PMC 2596726. PMID 17456670.
  • ^ Yang ZJ, Carter EL, Torbey MT, Martin LJ, Koehler RC (January 2010). "Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons". Experimental Neurology. 221 (1): 166–74. doi:10.1016/j.expneurol.2009.10.019. PMC 2812675. PMID 19883643.
  • ^ Yang S, Alkayed NJ, Hurn PD, Kirsch JR (March 2009). "Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP)". Anesthesia and Analgesia. 108 (3): 964–70. doi:10.1213/ane.0b013e318192442c. PMC 2828492. PMID 19224810.


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