Names
7-Hydroxy-N,N-dipropyl-2-aminotetralin[citation needed]
7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol[1]
Identifiers
3D model (JSmol)
Abbreviations
7-OH-DPAT
7-Hydroxy-2-N,N-dipropylaminotetralin
PubChem CID
CompTox Dashboard (EPA)
InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3 Y
Key: BLYMJBIZMIGWFK-UHFFFAOYSA-N Y
InChI=1/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
Key: BLYMJBIZMIGWFK-UHFFFAOYAH
CCCN(CCC)C1CCc2ccc(O)cc2C1
CCCN(CCC)C1CCC2=C(C1)C=C(O)C=C2
Properties
C16H25NO
247.382 g·mol−1
3.653
Acidity (pKa)
10.389
Basicity (pKb)
3.608
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
7-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with reasonable selectivity for the D3 receptor subtype,[2][3][4] and low affinity for serotonin receptors, unlike its structural isomer 8-OH-DPAT.[5][6][7] 7-OH-DPAT is self-administered in several animal models, and is used to study its addiction effects to cocaine.[8][9][10][11][12]
PAMs
Antagonists
Antagonists