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| Names | |
|---|---|
| Preferred IUPAC name
(1R,3S)-3-(Adamantan-1-yl)-1-(aminomethyl)-1H-2-benzopyran-5,6-diol | |
| Identifiers | |
 Y | |
3D model (JSmol) |
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| ChEMBL | |
| ChemSpider |
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PubChem CID |
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| UNII |
Y |
CompTox Dashboard (EPA) |
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| Properties | |
| C20H27NO3 | |
| Molar mass | 329.440 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
A-77636 is a synthetic drug which acts as a selective D1 receptor full agonist.[1] It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies,[2][3][4][5][6] but its high potency and long duration of action causes D1 receptor downregulation and tachyphylaxis,[7][8][9] and unlike other D1 full agonists such as SKF-82,958, it does not produce place preference in animals.[10] A-77636 partially substituted for cocaine in animal studies, and has been suggested for use as a possible substitute drug in treating addiction,[11] but it is better known for its use in studying the role of D1 receptors in the brain.[12][13][14]
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| D1-like |
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| D2-like |
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