APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene.[5][6][7]
Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.[7]
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC1 and a complementation factor encoded by this gene.[8] The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.[7]
Its deletion results in lethality in mice.[9]
A1CF has been shown to interact with APOBEC1,[10][11] CUGBP2,[12] and SYNCRIP.[13][10]
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PDB gallery
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2cpd: Solution structure of the RNA recognition motif of human APOBEC-1 complementation factor, ACF
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