Contents

ABCA8

Protein-coding gene in the species Homo sapiens

ABCA8
Identifiers
Aliases	ABCA8, ATP binding cassette subfamily A member 8
External IDs	OMIM: 612505; MGI: 1351668; HomoloGene: 56029; GeneCards: ABCA8; OMA:ABCA8 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 68,867,289 bp[1] End 68,955,392 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 72.88 cM Start 109,823,016 bp[2] End 109,886,671 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia trigeminal ganglion parietal pleura pericardium tibial nerve cardiac muscle tissue of right atrium germinal epithelium corpus callosum sural nerve vena cava Top expressed in lumbar spinal ganglion muscle of thigh liver neural layer of retina left lobe of liver dentate gyrus of hippocampal formation granule cell esophagus extraocular muscle upper arm triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity ATP binding ABC-type xenobiotic transporter activity ATPase-coupled transmembrane transporter activity lipid transporter activity Cellular component integral component of membrane plasma membrane membrane mitochondrial inner membrane intracellular membrane-bounded organelle Biological process lipid transport xenobiotic transport xenobiotic transmembrane transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10351 27404 Ensembl ENSG00000141338 ENSMUSG00000020620 UniProt O94911 Q8K440 RefSeq (mRNA) NM_001288985 NM_001288986 NM_007168 NM_001375771 NM_001375772 NM_013851 NM_001362749 RefSeq (protein) NP_001275914 NP_001275915 NP_009099 NP_001362700 NP_001362701 NP_038879 NP_001349678 Location (UCSC) Chr 17: 68.87 – 68.96 Mb Chr 11: 109.82 – 109.89 Mb PubMed search [3] [4]
Wikidata
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ATP-binding cassette sub-family A member 8 is a protein that in humans is encoded by the ABCA8 gene.^[5]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined.^[5]

References[edit]

Further reading[edit]

External links[edit]

• ABCA8 human gene location in the UCSC Genome Browser.
• ABCA8 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.