ATP-binding cassette sub-family G member 8 is a protein that in humans is encoded by the ABCG8 gene.[5][6][7]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.[7]
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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see also ABC transporter disorders |
Lipids: lipoprotein particle metabolism
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Lipoprotein particle classes and subclasses |
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Extracellular enzymes |
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Lipid transfer proteins |
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Cell surface receptors |
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ATP-binding cassette transporter |
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