Contents

ACTL6B

Protein-coding gene in the species Homo sapiens

ACTL6B
Identifiers
Aliases	ACTL6B, ACTL6, BAF53B, arpNalpha, actin like 6B, EIEE76, IDDSSAD, DEE76, SMARCN2
External IDs	OMIM: 612458; MGI: 1933548; HomoloGene: 81844; GeneCards: ACTL6B; OMA:ACTL6B - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,643,097 bp[1] End 100,656,448 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,553,517 bp[2] End 137,569,582 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe ganglionic eminence Brodmann area 9 prefrontal cortex nucleus accumbens cingulate gyrus anterior cingulate cortex putamen caudate nucleus Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex perirhinal cortex subiculum entorhinal cortex cerebellar cortex olfactory tubercle dorsomedial hypothalamic nucleus CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton transcription coactivator activity chromatin binding Cellular component nucleus nucleolus nBAF complex SWI/SNF complex NuA4 histone acetyltransferase complex Biological process nervous system development regulation of transcription, DNA-templated spinal cord development regulation of transcription by RNA polymerase II transcription, DNA-templated chromatin remodeling cytoskeleton organization chromatin organization positive regulation of nucleic acid-templated transcription histone H4 acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51412 83766 Ensembl ENSG00000077080 ENSMUSG00000029712 UniProt O94805 Q99MR0 RefSeq (mRNA) NM_016188 NM_031404 RefSeq (protein) NP_057272 NP_113581 Location (UCSC) Chr 7: 100.64 – 100.66 Mb Chr 5: 137.55 – 137.57 Mb PubMed search [3] [4]
Wikidata
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Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.^[5][6]

Function[edit]

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.^[6]

Interactions[edit]

ACTL6B has been shown to interact with CTBP1.^[7]

References[edit]

External links[edit]

• Human ACTL6B genome location and ACTL6B gene details page in the UCSC Genome Browser.

Further reading[edit]

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