ACY1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | ACY1, ACY-1, ACY1D, HEL-S-5, aminoacylase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 104620; MGI: 87913; HomoloGene: 110440; GeneCards: ACY1; OMA:ACY1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene.[5][6][7]
Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosityinsmall-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.[7]
Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
| |
---|---|
3.5.1: Linear amides / Amidohydrolases |
|
3.5.2: Cyclic amides/ Amidohydrolases |
|
3.5.3: Linear amidines/ Ureohydrolases |
|
3.5.4: Cyclic amidines/ Aminohydrolases |
|
3.5.5: Nitriles/ Aminohydrolases |
|
3.5.99: Other |
|
This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it. |