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AKT1S1

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AKT1S1

Identifiers

Aliases

AKT1S1, Lobe, PRAS40, AKT1 substrate 1

External IDs

OMIM: 610221; MGI: 1914855; HomoloGene: 12162; GeneCards: AKT1S1; OMA:AKT1S1 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	49,869,033 bp^[1]
Band	19q13.33	End	49,878,459 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B3	Start	44,498,415 bp^[2]
Band	7\|7 B3	End	44,504,845 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

muscle of thigh

right adrenal gland

right adrenal cortex

left adrenal gland

left adrenal cortex

mucosa of transverse colon

skin of leg

apex of heart

gastric mucosa

Top expressed in

muscle of thigh

yolk sac

extensor digitorum longus muscle

knee joint

molar

lip

vastus lateralis muscle

atrium

esophagus

plantaris muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	TORC1 complex nucleus nucleoplasm cytoplasm cytosol protein-containing complex
Biological process	regulation of cellular response to heat negative regulation of TOR signaling regulation of neuron apoptotic process negative regulation of protein kinase activity negative regulation of cell size neurotrophin TRK receptor signaling pathway TORC1 signaling regulation of apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84335


67605

Ensembl


ENSG00000204673


ENSMUSG00000011096

UniProt


Q96B36


Q9D1F4

RefSeq (mRNA)


NM_032375 NM_001098632 NM_001098633 NM_001278159 NM_001278160

NM_001253920 NM_001290694 NM_001290695 NM_026270 NM_001382480
NM_001382481 NM_001382482 NM_001382483 NM_001382484

RefSeq (protein)


NP_001092102 NP_001092103 NP_001265088 NP_001265089 NP_115751

NP_001240849 NP_001277623 NP_001277624 NP_080546 NP_001369409
NP_001369410 NP_001369411 NP_001369412 NP_001369413

Location (UCSC)

Chr 19: 49.87 – 49.88 Mb

Chr 7: 44.5 – 44.5 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.^[5]^[6]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204673 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000011096 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry. 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.

^ "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH (Feb 2004). "Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor". The Journal of Neuroscience. 24 (7): 1584–93. doi:10.1523/JNEUROSCI.5209-03.2004. PMC 6730448. PMID 14973226.

Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

Huang B, Porter G (Oct 2005). "Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis". Acta Pharmacologica Sinica. 26 (10): 1253–8. doi:10.1111/j.1745-7254.2005.00184.x. PMID 16174443.

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40". Nature Cell Biology. 9 (3): 316–23. doi:10.1038/ncb1547. PMID 17277771. S2CID 12827916.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell. 25 (6): 903–15. doi:10.1016/j.molcel.2007.03.003. PMID 17386266.

Wang L, Harris TE, Roth RA, Lawrence JC (Jul 2007). "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding". The Journal of Biological Chemistry. 282 (27): 20036–44. doi:10.1074/jbc.M702376200. PMID 17510057.

Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (Aug 2007). "PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex". The Journal of Biological Chemistry. 282 (34): 24514–24. doi:10.1074/jbc.M704406200. PMID 17604271.

External links

[edit]

Human AKT1S1 genome location and AKT1S1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=AKT1S1&oldid=1212480046" Categories: ●Genes on human chromosome 19 ●Human chromosome 19 gene stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●All stub articles ●This page was last edited on 8 March 2024, at 02:34 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view