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ALG11

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ALG11

Identifiers

Aliases

ALG11, CDG1P, GT8, alpha-1,2-mannosyltransferase, ALG11 alpha-1,2-mannosyltransferase

External IDs

OMIM: 613666; MGI: 2142632; HomoloGene: 68893; GeneCards: ALG11; OMA:ALG11 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q14.3	Start	52,012,391 bp^[1]
Band	13q14.3	End	52,079,232 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 A2	Start	22,550,737 bp^[2]
Band	8\|8 A2	End	22,561,643 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

Achilles tendon

endometrium

epithelium of colon

gonad

bone marrow cells

placenta

tonsil

corpus callosum

testicle

Top expressed in

spermatocyte

genital tubercle

hand

tail of embryo

supraoptic nucleus

seminal vesicula

superior cervical ganglion

medullary collecting duct

trigeminal ganglion

substantia nigra

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity glycosyltransferase activity GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
Cellular component	integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane
Biological process	mannosylation oligosaccharide-lipid intermediate biosynthetic process protein N-linked glycosylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


440138


207958

Ensembl


ENSG00000253710


ENSMUSG00000063362

UniProt


Q2TAA5


Q3TZM9

RefSeq (mRNA)


NM_001004127


NM_001243161 NM_183142

RefSeq (protein)


NP_001004127


NP_001230090 NP_898965

Location (UCSC)

Chr 13: 52.01 – 52.08 Mb

Chr 8: 22.55 – 22.56 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Asparagine-linked glycosylation protein 11 is an enzyme encoded by the ALG11 gene.^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000253710 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063362 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: asparagine-linked glycosylation 11".

^ Cipollo, JF; Trimble, RB; Chi, JH; Yan, Q; Dean, N (2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem. 276 (24): 21828–40. doi:10.1074/jbc.m010896200. PMID 11278778.

^ Gao, XD; Nishikawa, A; Dean, N. (Jun 2004). "Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. 2004". Glycobiology. 14 (6): 559–70. CiteSeerX 10.1.1.572.6611. doi:10.1093/glycob/cwh072. PMID 15044395.

External links[edit]

Human ALG11 genome location and ALG11 gene details page in the UCSC Genome Browser.

Further reading[edit]

Rohozinski J, Lamb DJ, Bishop CE (2006). "UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man". Biol. Reprod. 74 (4): 644–51. doi:10.1095/biolreprod.105.046698. PMID 16354793.

Rind N, Schmeiser V, Thiel C, et al. (2010). "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip". Hum. Mol. Genet. 19 (8): 1413–24. doi:10.1093/hmg/ddq016. PMID 20080937.

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N (June 2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem. 276 (24): 21828–40. doi:10.1074/jbc.M010896200. PMID 11278778.

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