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Contents

   



(Top)
  


1 See also  




2 References  













AM-087






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From Wikipedia, the free encyclopedia
  

AM-087
Identifiers

  • (6aR,10aR)-3-(2-Methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol

CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H33BrO2
Molar mass421.419 g·mol−1
3D model (JSmol)

  • CC3(C)C1CC=C(C)CC1c2c(O)cc(C(C)(C)CCCCBr)cc2O3

  • InChI=1S/C23H33BrO2/c1-15-8-9-18-17(12-15)21-19(25)13-16(14-20(21)26-23(18,4)5)22(2,3)10-6-7-11-24/h8,13-14,17-18,25H,6-7,9-12H2,1-5H3/t17-,18-/m1/s1 checkY

  • Key:RJPGJHLVEUSRRA-QZTJIDSGSA-N checkY

  (verify)

AM-087 (part of the AM cannabinoid series) is an analgesic drug which acts as a cannabinoid agonist.[1] It is a derivative of Δ8-THC, substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43 nM, making it around 100 times more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[2]

See also[edit]

References[edit]

  1. ^ Martin BR, Compton DR, Semus SF, Lin S, Marciniak G, Grzybowska J, et al. (October 1993). "Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC". Pharmacology, Biochemistry, and Behavior. 46 (2): 295–301. doi:10.1016/0091-3057(93)90356-X. PMID 8265683. S2CID 140209578.
  • ^ Charalambous A, Lin S, Marciniak G, Banijamali A, Friend FL, Compton DR, et al. (November 1991). "Pharmacological evaluation of halogenated delta 8-THC analogs". Pharmacology, Biochemistry, and Behavior. 40 (3): 509–12. doi:10.1016/0091-3057(91)90355-6. PMID 1666915. S2CID 140209927.


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