ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor familyofGTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosisofplasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.
This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.[5]
ARF6 can interact with βarrestin upon receptor activation.
ARF6 has been shown to interact with:
PDB gallery
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1e0s: SMALL G PROTEIN ARF6-GDP
2a5d: Structural basis for the activation of cholera toxin by human ARF6-GTP
2a5f: Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6
2a5g: Cholera toxin A1 subunit bound to ARF6(Q67L)
2j5x: STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS
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3.6.1 |
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3.6.2 |
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3.6.3-4: ATPase |
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3.6.5: GTPase |
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