Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.[5][6][7]
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.[7]
ARPC2 has been shown to interact with Cortactin.[8]
PDB gallery
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1k8k: Crystal Structure of Arp2/3 Complex
1tyq: Crystal structure of Arp2/3 complex with bound ATP and calcium
1u2v: Crystal structure of Arp2/3 complex with bound ADP and calcium
2p9i: Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde
2p9k: Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with glutaraldehyde
2p9l: Crystal Structure of bovine Arp2/3 complex
2p9n: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
2p9p: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
2p9s: Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+
2p9u: Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium
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