ATG4D | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ATG4D, APG4-D, APG4D, AUTL4, autophagy related 4D cysteine peptidase, HsAPG4D | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611340; MGI: 2444308; HomoloGene: 13156; GeneCards: ATG4D; OMA:ATG4D - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[5]
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.
This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |