Acquired progressive lymphangioma, also known as benign lymphangioendothelioma is a group of lymphangiomas that occur anywhere in young individuals, grow slowly, and present as bruise-like lesions or erythematous macules.[1]: 597 Acquired progressive lymphangioma may develop following radiation therapy, surgery, trauma, inflammation, and tick bites. The treatment of choice is complete surgical excision.
Acquired progressive lymphangioma appears as a slowly growing erythaematous to brownish, bruise-like, macule, plaque, or nodule typically located on the legs, head or neck.[2] The lesions are usually asymptomatic.[3]
Because acquired progressive lymphangioma has been described following various traumas, it is thought to be a response to various inflammatory stimuli rather than a real neoplasm.[10]
Another possible pathogenic explanation is hormonal stimulation, as quickly growing lesions have been observed in numerous pubescent and prepubescent individuals.[11]
Acquired progressive lymphangioma has thin-walled endothelial-lined gaps interspersed between collagen strands.[2]Endothelial cells show positive staining for lymphatic markers as podoplanin (D2-40), LYVE-1, and PROX-1. Additionally, the cells have variable levels of factor VIII, Ulex europaeus agglutinin I, CD31, and CD34.[10]
^James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN0-7216-2921-0.
^ abcJones, Edward Wilson; Winkelmann, R.K.; Zachary, C.B.; Reda, Ashraf M. (1990). "Benign lymphangioendothelioma". Journal of the American Academy of Dermatology. 23 (2). Elsevier BV: 229–235. doi:10.1016/0190-9622(90)70203-t. ISSN0190-9622. PMID2212118.
^Rosso, R.; Gianelli, U.; Carnevali, L. (1995). "Acquired progressive lymphangioma of the skin following radiotherapy for breast carcinoma". Journal of Cutaneous Pathology. 22 (2). Wiley: 164–167. doi:10.1111/j.1600-0560.1995.tb01401.x. ISSN0303-6987. PMID7560351.
^Grunwald, Marcelo H.; Amichai, Boaz; Avinoach, Ilana (1997). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 37 (4). Elsevier BV: 656–657. doi:10.1016/s0190-9622(97)70192-0. ISSN0190-9622. PMID9344213.
^Watanabe, Makoto; Kishiyama, Kazunori; Ohkawara, Akira (1983). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 8 (5). Elsevier BV: 663–667. doi:10.1016/s0190-9622(83)70076-9. ISSN0190-9622. PMID6863623.
^Kato, H.; Kadoya, A. (1996). "Acquired progressive lymphangioma occurring following femoral arteriography". Clinical and Experimental Dermatology. 21 (2): 159–162. doi:10.1111/j.1365-2230.1996.tb00044.x. PMID8759209.
^Wilmera, Axel; Kaatza, Martin; Mentzelb, Thomas; Wollinaa, Uwe (1998). "Lymphangioendothelioma after a tick bite". Journal of the American Academy of Dermatology. 39 (1): 126–128. doi:10.1016/S0190-9622(98)70416-5. PMID9674411.
^Zhu, Wen-Yuan; Penneys, Neal S.; Reyes, Blas; Khatib, Ziad; Schachner, Lawrence (1991). "Acquired progressive lymphangioma". Journal of the American Academy of Dermatology. 24 (5). Elsevier BV: 813–815. doi:10.1016/0190-9622(91)70120-q. ISSN0190-9622. PMID2050845.
Guillou, Louis; Fletcher, Christopher D. M. (2000). "Benign Lymphangioendothelioma (Acquired Progressive Lymphangioma): A Lesion Not to Be Confused With Well-Differentiated Angiosarcoma and Patch Stage Kaposi's Sarcoma". The American Journal of Surgical Pathology. 24 (8). Ovid Technologies (Wolters Kluwer Health): 1047–1057. doi:10.1097/00000478-200008000-00002. ISSN0147-5185.
