While most of Yazawa's manga is published in Japan by Shueisha, publishers of Ribon and Cookie (Nana was serialized in the latter), series like Paradise Kiss have appeared in non-Shueisha magazines such as Zipper, published by Shodensha.[2]
She also voiced an animated rendition of herself that made a cameo appearance in the final episode of the Neighborhood Story anime. All five volumes of Paradise Kiss were released in English by Vertical, Inc.Nana ran in now-defunct American manga magazine Shojo Beat. In 2003, Yazawa was awarded the Shogakukan Manga Award for Nana.[3]Nana was made into an anime (produced by Madhouse) and a successful movie with a sequel in Japan.
In June 2009, it was revealed that Yazawa had contracted a sudden illness, and had to be sent to the hospital for treatment, putting Nana on hiatus.[4] She returned from the hospital in April 2010, although it has yet to be revealed when or if she will be continuing Nana.[5]
Yazawa has worked on a variety of small illustrative projects since putting Nana on hold. She provided artwork for singer JUJU's single Iiwake in 2017 and a celebratory illustration for Space Channel 5 VR in 2020, drew a mini-manga featuring characters from her series Tenshi Nanka Ja Nai and Neighborhood Story in 2016, contributed new images to the 2015 Nana calendar, and published a new "Junko's Room" chapter, her first new manga in over three years, in 2013.[6]
Yazawa's storylines are generally centered on young women and their relationships. The characters are always very stylish, and she is known especially for her hip sense of fashion. Yazawa herself attended a fashion school after high school but did not complete her studies there. Another key point is her often rebellious characters, who tend to be juxtaposed against the more traditional ones.[7]
She been compared to fellow manga artist Taku Tsumugi for her play with depth and layering.[8]