In 1898 Liverpool Corporation acquired land from the Harbreck estate with which to build a hospital.[2] The hospital, initially known as the "City Hospital North, Fazakerley, for Infectious Diseases" opened in 1906.[3] During the First World War, the building was requisitioned by the War Office to create the 1st Western General Hospital, a facility for the Royal Army Medical Corps to treat military casualties.[2] It became the "Fazakerley Infectious Hospital" in 1947 and, after joining the National Health Service in 1948, became the Fazakerley Hospital in 1968.[3] The maternity unit was completed in 1969 and, after a major-rebuilding programme, the hospital reopened as the "Fazakerley District General Hospital" in 1974.[3] It became the "University Hospital Aintree" in 1999.[3]
In July 2016 the hospital, together with the Walton Centre, became the single receiving site for major trauma patients in Merseyside.[4] An expanded urgent care and trauma centre was officially opened by the Duke of Cambridge in September 2017.[5]