The Rays promoted Colomé to the major leagues on May 29, 2013.[2] He started 3 games, posting a 2.25 earned run average (ERA).
On March 24, 2014, Colomé was suspended 50 games for failing a random drug test.[3] Colome ended the year 2–0 with a 2.66 ERA in 5 games, 3 of which were starts. Colomé saw his first significant playing time in 2015, most of it due to a switch to the bullpen, where he finished with 43 appearances and a 3.94 ERA.[citation needed]
In2016, Colomé was named the full-time closer for the Rays due to an injury to Brad Boxberger. He kept the role as closer. He finished the season with 37 saves, fourth in the AL, and ended the season with a 1.91 ERA.[4] Colome was also selected to his first career All-Star game.
In2017, Colomé became the sixth player in franchise history to reach 40 saves in a season;[5] he ended the season with 47 saves, which led the major leagues.[6]
On November 30, 2018, the Mariners traded Colomé to the Chicago White Sox in exchange for Omar Narváez.[8] With the 2020 Chicago White Sox, Colomé appeared in 21 games, compiling a 2–0 record with 0.81 ERA and 16 strikeouts in 22.1 innings pitched.[9]
On March 17, 2022, Colomé officially signed a one-year, $4.1 million contract with the Colorado Rockies.[11] Colomé appeared in 53 games for the Rockies, but struggled to a 2–7 record and 5.74 ERA with four saves and 32 strikeouts in 47.0 innings pitched.
On January 27, 2023, Colomé signed a minor league contract with the Washington Nationals organization.[12] He was released by the Nationals on March 29.[13]
On April 7, 2023, Colomé signed a minor league contract with the Chicago White Sox organization.[14] He made 8 appearances for the Triple-A Charlotte Knights, registering a 2.25 ERA with 7 strikeouts and 1 save in 8.0 innings pitched. On May 2, Colomé had his contract selected to the active roster.[15] He made 4 appearances for the White Sox, surrendering 2 runs in 3.0 innings of work. On May 10, Colomé was designated for assignment following the promotion of Jake Marisnick.[16] He cleared waivers and was sent outright to Charlotte on May 12.[17] Colomé was released by the White Sox organization on August 3.[18]
On February 23, 2024, Colomé signed with the Saraperos de Saltillo of the Mexican League.[19] In 19 games for Saltillo, he posted a 5.29 ERA with 14 strikeouts and 8 saves across 17 innings pitched. On June 4, Colomé was released by the Saraperos.[20]
