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Contents

   



(Top)
  


1 Side effects  




2 Legality  




3 See also  




4 References  













alpha-Pyrrolidinopentiothiophenone






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From Wikipedia, the free encyclopedia
  

alpha-Pyrrolidinopentiothiophenone
Legal status
Legal status
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • UK: Class B
  • Illegal in China, Sweden and Switzerland
    • Identifiers

    • 2-(Pyrrolidin-1-yl)-1-(thiophen-2-yl)pentan-1-one

    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC13H19NOS
    Molar mass237.36 g·mol−1
    3D model (JSmol)

    • CCCC(N1CCCC1)C(=O)c2sccc2

    • InChI=1S/C13H19NOS/c1-2-6-11(14-8-3-4-9-14)13(15)12-7-5-10-16-12/h5,7,10-11H,2-4,6,8-9H2,1H3

    • Key:OOSRPGUQJAKBLV-UHFFFAOYSA-N

    α-Pyrro​lidino​pentio​thiophenone (also known as α-PVT) is a synthetic stimulant of the cathinone class that has been sold online as a designer drug.[1][2][3] It is an analogueofα-PVP where the phenyl ring has been replaced by thiophene.

    α-PVT was first identified in Japan in 2013.[4] Its metabolism has been described in literature.[5][6]

    It produces stimulating effects in humans, according to the individuals who have tried it. Most of the individuals who have tried it prefer α-PVP and α-PPP to it.

    Side effects[edit]

    α-PVT has been shown to possess high cytotoxicity against human cell lines.[7]

    Legality[edit]

    Sweden's public health agency suggested classifying α-PVT as hazardous substance on November 10, 2014.[8]

    As of October 2015 α-PVT is a controlled substance in China.[9]

    α-PVT is illegal in Switzerland as of December 2015.[10]

    See also[edit]

    References[edit]

    1. ^ "α-Pyrrolidinopentiothiophenone". Cayman Chemical. Retrieved 29 June 2015.
  • ^ Concheiro M, Castaneto M, Kronstrand R, Huestis MA (June 2015). "Simultaneous determination of 40 novel psychoactive stimulants in urine by liquid chromatography-high resolution mass spectrometry and library matching". Journal of Chromatography A. 1397 (5): 32–42. doi:10.1016/j.chroma.2015.04.002. PMC 4433760. PMID 25931378.
  • ^ Doi T, Asada A, Takeda A, Tagami T, Katagi M, Matsuta S, et al. (January 2016). "Identification and characterization of α-PVT, α-PBT, and their bromothienyl analogs found in illicit drug products". Forensic Toxicology. 34 (1): 76–93. doi:10.1007/s11419-015-0288-3. S2CID 24528511.
  • ^ Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y (July 2013). "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology. 31 (2): 223–240. doi:10.1007/s11419-013-0182-9. S2CID 1279637.
  • ^ Takayama T, Suzuki M, Todoroki K, Inoue K, Min JZ, Kikura-Hanajiri R, et al. (June 2014). "UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC and α-PVT, by human liver microsome". Biomedical Chromatography. 28 (6): 831–838. doi:10.1002/bmc.3155. PMID 24861751.
  • ^ Swortwood MJ, Carlier J, Ellefsen KN, Wohlfarth A, Diao X, Concheiro-Guisan M, et al. (January 2016). "In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant". Bioanalysis. 8 (1): 65–82. doi:10.4155/bio.15.237. PMC 5493968. PMID 26648097.
  • ^ Wojcieszak J, Andrzejczak D, Woldan-Tambor A, Zawilska JB (August 2016). "Cytotoxic Activity of Pyrovalerone Derivatives, an Emerging Group of Psychostimulant Designer Cathinones". Neurotoxicity Research. 30 (2): 239–250. doi:10.1007/s12640-016-9640-6. PMID 27295059. S2CID 11202107.
  • ^ "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). Retrieved 29 June 2015.
  • ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  • ^ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Alpha-Pyrrolidinopentiothiophenone&oldid=1222012798"
    Categories: 
    ●Cathinones
     ●Designer drugs
     ●Norepinephrine–dopamine reuptake inhibitors
     ●1-Pyrrolidinyl compounds
     ●Stimulants
     ●Thiophenes
     ●Nervous system drug stubs
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    ●This page was last edited on 3 May 2024, at 10:18 (UTC).
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