Amfecloral
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Other names | alpha-methyl-N-(2,2,2-trichloroethylidene)phenethylamine; N-(2,2,2-trichloroethylidene)amphetamine |
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Formula | C11H12Cl3N |
Molar mass | 264.57 g·mol−1 |
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Amfecloral (INN), also known as amphecloral (USAN), is a stimulant drug of the phenethylamine and amphetamine chemical classes that was used as an appetite suppressant under the trade name Acutran, but is now no longer marketed.[1] It was classified as an anorectic drug with little to no stimulant activity in a 1970 review.[2] The British Pharmacopoeia Commission approved the name in 1970.[3] The raw ingredients used in manufacturing it were d-amphetamine and chloral hydrate.[4]
Pharmacology
[edit]Amfecloral is metabolised to both d-(S)- and l-(R)-amphetamine and, most likely, also to chloral hydrate.[5] Amphetamine is a psychostimulant, whereas chloral hydrate is a sedative/hypnotic drug.
The extent of metabolism and in-vivo contribution of a chloral hydrate metabolism to its purported "little to no stimulant activity" is unknown.
See also
[edit]References
[edit]- ^ a b Ganellin CR, Triggle DJ (1996). Dictionary of pharmacological agents, Volumes 1-2. Chapman & Hall. p. 67. ISBN 9780412466304.
- ^ Van Rossum JM (1970). "Mode of action of psychomotor stimulant drugs". International Review of Neurobiology. 12: 307–83. doi:10.1016/s0074-7742(08)60065-3. ISBN 9780123668127. PMID 4918147.
- ^ "Notes and News". The Lancet. 296 (7675): 730–732. October 1970. doi:10.1016/S0140-6736(70)92010-6.
- ^ McPherson EM (2007). Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Burlington: Elsevier. p. 244. ISBN 9780815518563.
- ^ "NCATS Inxight Drugs — AMFECLORAL, (+)-". drugs.ncats.io. Retrieved 2024-07-16.
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See also: Receptor/signaling modulators • Monoamine reuptake inhibitors • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins |
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