Clinical data
Legal status
Identifiers
5-phenyl-1,3-thiazole-2,4-diamine
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
C9H9N3S
191.25 g·mol−1
3D model (JSmol)
C1=CC=C(C=C1)C2=C(N=C(S2)N)N
InChI=1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12) Y
Key:UPOYFZYFGWBUKL-UHFFFAOYSA-N Y
Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturateoropiate overdose, usually in combination with bemegride,[1][2] as well as poisoning from other sedative drugs[3][4] and treatment of respiratory failure from other causes.[5] It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia.[6][7] It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagonists such as naloxone.[8][9]
Respiratory stimulants
5-HT4 receptor agonists
Other agents for treating respiratory depression
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