AnApocrine nevus is an extremely rare cutaneous condition that is composed of hyperplastic mature apocrine glands.[1]: 775 Apocrine nevi present as a nodular skin-coloured lump. They are typically asymptomatic. Apocrine nevi can be congenital and they have been associated with other disorders.
Apocrine nevi manifests as a persistent pedunculated or nodular skin-coloured axillary lump.[2] Additionally, reports of them occurring on the face,[3][4] scalp,[5] chest,[6] and inguinal area have been made.[7] The majority of the time, apocrine nevi are asymptomatic, although some individuals describe minor pain, baldness, or in rare cases, leakage.[8][9]
According to histopathology, apocrine nevi are made up of several mature apocrine sweat glands grouped in lobules that invade the dermis and/or hypodermis and cause normal skin structures to be displaced. There may be some cystic dilatation of the lumina in these glands.[11]
^Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN0-07-138076-0.
^Cordero, Steven C; Royer, Michael C; Rush, Walter L; Hallman, James R; Lupton, George P (2012). "Pure Apocrine Nevus". The American Journal of Dermatopathology. 34 (3). Ovid Technologies (Wolters Kluwer Health): 305–309. doi:10.1097/dad.0b013e31823adf0e. ISSN0193-1091. PMID22317889.
^Schwartz, Robert A.; Rojas-Corona, Rogelio; Lambert, W. Clark (1984). "The polymorphic apocrine nevus: A study of a unique tumor including carcinoembryonic antigen staining". Journal of Surgical Oncology. 26 (3). Wiley: 183–186. doi:10.1002/jso.2930260309. ISSN0022-4790. PMID6738068.
^BURDEN, PATRICIA A.; GENTRY, RICHARD H.; FITZPATRICK, JAMES E. (1987). "Piloleiomyoma Arising in an Organoid Nevus: A Case Report and Review of the Literature". The Journal of Dermatologic Surgery and Oncology. 13 (11). Wiley: 1213–1222. doi:10.1111/j.1524-4725.1987.tb02433.x. ISSN0148-0812. PMID3312332.
^ abNeill, J. S. A.; Park, H. Kim (1993). "Apocrine nevus: light microscopic, immunohistochemical and ultrastructural studies of a case". Journal of Cutaneous Pathology. 20 (1). Wiley: 79–83. doi:10.1111/j.1600-0560.1993.tb01255.x. ISSN0303-6987. PMID8468422.
^ abHerrmann, James J.; Eramo, Lynne R. (1995). "Congenital Apocrine Hamartoma: An Unusual Clinical Variant of Organoid Nevus with Apocrine Differentiation". Pediatric Dermatology. 12 (3). Wiley: 248–251. doi:10.1111/j.1525-1470.1995.tb00170.x. ISSN0736-8046. PMID7501558.
^Vakilzadeh, Fereydoun; Happle, Rudolf; Peters, Peter; Macher, Egon (1976). "Fokale dermale hypoplasie mit apokrinen naevi und streifenförmiger anomalie der knochen". Archives of Dermatological Research (in German). 256 (2): 189–195. doi:10.1007/BF00567364. ISSN0340-3696. PMID822789.
^Kanitakis, J.; Kyamidis, K.; Toussinas, A.; Tsoïtis, G. (2011). "Pure Apocrine Nevus: Immunohistochemical Study of a New Case and Literature Review". Dermatology. 222 (2): 97–101. doi:10.1159/000323000. ISSN1018-8665. PMID21212656.
Ando, Ko-ichi; Hashikawa, Yuko; Nakashima, Mikio; Nakayama, Atsuo; Ohashi, Masaru (1991). "Pure Apocrine Nevus A Study of Light-Microscopic and Immunohistochemical Features of a Rare Tumor". The American Journal of Dermatopathology. 13 (1). Ovid Technologies (Wolters Kluwer Health): 71–76. doi:10.1097/00000372-199102000-00012. ISSN0193-1091. PMID2003651.
