Picker began his career by following in his father's footsteps. In 1935, he started with Columbia Pictures, where his father had been an executive, and later became head of international distribution. He then joined United Artists where his nephew, future UA president David worked, and in 1961 he was made an executive vice president in charge of all production.[3][4] His brother Eugene joined UA the same year.[4][3] His motion picture career ended and political career began when President Lyndon B. Johnson named him to the International Commission on Education and Cultural Affairs.
Although his career in the motion picture industry ended in the 1960s, Picker continued to be an active force in the field. He helped establish the Washington-based American Film Institute. He later served as chairman of the board of the National Center for Jewish Film. The center at Brandeis University is dedicated to restoring Yiddish film classics. He also helped found the Holocaust Documentation and Education Center based at Florida International University.
In 1957, he married Ruth Cohen; they had two daughters, Carol Picker Frank and Phyllis Picker Dessner.[1] Picker died of pneumonia at New England Deaconess Hospital in Boston.[1][5]