Contents

Arotinolol

Chemical compound

Arotinolol

Clinical data
Trade names	Almarl
Other names	S-596
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral (tablets)
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	2 hours
Elimination half-life	10 hours
Identifiers
IUPAC name (RS)-5-(2-{[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl}- 1,3-thiazol-4-yl)thiophene-2-carboxamide
CAS Number	68377-92-4 N
PubChem CID	2239
ChemSpider	2152 Y
UNII	394E3P3B99
KEGG	D07465 Y
ChEMBL	ChEMBL93298 Y
CompTox Dashboard (EPA)	DTXSID3022619
Chemical and physical data
Formula	C15H21N3O2S3
Molar mass	371.53 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C)NCC(CSC1=NC(=CS1)C2=CC=C(S2)C(=O)N)O
InChI InChI=1S/C15H21N3O2S3/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20) Y Key:BHIAIPWSVYSKJS-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers.^[1] It also acts as a β₃ receptor agonist.^[2] A 1979 publication suggests arotinolol as having first been described in the scientific literature by Sumitomo Chemical as "β-adrenergic blocking, antiarrhythmic compound S-596".^[3]

Medical uses[edit]

It is used in the treatment of high blood pressure^[4] and essential tremor.^[5][6] Recommended dosage is 10 to 30 mg per day.^{[citation needed]}

References[edit]

^ Hara Y, Sato E, Miyagishi A, Aono S, Nakatani H (1979). "新しいβ-受容体遮断薬，dl-2-(3'-t-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)-thiazole hydrochloride (S-596) の薬理作用" [Pharmacological properties of dl-2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole hydrochloride (S-596), a new β-adrenergic blocking agent]. Folia Pharmacologica Japonica (English abstract) (in Japanese). 75 (7): 707–720. doi:10.1254/fpj.75.707. ISSN 1347-8397.

^ Wu H, Zhang Y, Huang J, Zhang Y, Liu G, Sun N, et al. (September 2001). "Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers" (PDF). Hypertension Research. 24 (5): 605–610. doi:10.1291/hypres.24.605. PMID 11675958.

^ Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D (August 2003). "A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor". Parkinsonism & Related Disorders. 9 (6): 341–347. doi:10.1016/S1353-8020(03)00029-4. PMID 12853233.

External links[edit]

• (in Japanese) Almarl Full Prescribing Information. Revised November 2009 Sumitomo Dainippon Pharma Co., Ltd.
• (in Japanese) Official Sumitomo Dainippon Pharma Website Archived 2020-07-01 at the Wayback Machine
• "Arotinolol Hydrochloride". Drug Monograph. Drug Information Research Institute. Archived from the original on 2011-07-22.