Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.[5][6]
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.[6] Beta-arrestin has been shown to play a role as a scaffold that binds intermediates and may direct G-protein signaling by connecting receptors to clathrin-mediated endocytosis.[7]
Arrestin beta 1 has been shown to interact with
PDB gallery
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1g4m: CRYSTAL STRUCTURE OF BOVINE BETA-ARRESTIN 1
1g4r: CRYSTAL STRUCTURE OF BOVINE BETA-ARRESTIN 1
1jsy: Crystal structure of bovine arrestin-2
1zsh: Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6)
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Arrestin |
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Membrane-spanning 4A |
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Myelin |
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Pulmonary surfactant |
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Tetraspanin |
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Other/ungrouped |
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