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An arsenical keratosis is a growth of keratin on the skin caused by arsenic ,[1] : 725 Earth's crust and is widely distributed in the environment,[2] industrial , agricultural , and medicinal substances. Arsenic is also found to be an environmental contaminant in drinking water (well water) and an occupational hazard for miners and glass workers.[3] : 640 Bowen's disease ,[4] cardiovascular diseases , developmental abnormalities , neurologic and neurobehavioral disorders , diabetes , hearing loss , hematologic disorders , and various types of cancer .[5] squamous cell carcinoma . Metastatic arsenic squamous cell carcinoma and arsenic-induced malignancies in internal organs such as the bladder , kidney , skin , liver , and colon , may result in death.[5]
Signs and symptoms [ edit ]
Books talk about diffuse ketarosic neoformations in palms and plants, which can evolve into basal cell carcinoma. These neoformations are usually yellowish.
Pathophysiology [ edit ]
Arsenite impairs nucleotide excision repair ,[6] gene expression by increasing or decreasing DNA methylation . The high affinity of arsenic for sulfhydryl groups makes keratin-rich cells (e.g., epidermal keratinocytes ) a sensitive target for arsenic-induced toxicity. Arsenic has been shown to alter epidermal keratinocyte differentiation processes,[7] growth factors ,[8]
Treatment [ edit ]
References [ edit ]
^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine . (6th ed.). McGraw-Hill. ISBN 0-07-138076-0 .
^ Duker AA, Carranza EJ, Hale M (July 2005). "Arsenic geochemistry and health". Environ Int 31 5 ): 631–41. doi :10.1016/j.envint.2004.10.020 . PMID 15910959 .
^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology . Saunders Elsevier. ISBN 0-7216-2921-0
^ a b Yerebakan O, Ermis O, Yilmaz E, Basaran E (February 2002). "Treatment of arsenical keratosis and Bowen's disease with acitretin" . Int. J. Dermatol. 41 2 ): 84–7. doi :10.1046/j.1365-4362.2002.01372.x PMID 11982642 .
^ a b Tchounwou PB, Centeno JA, Patlolla AK (January 2004). "Arsenic toxicity, mutagenesis, and carcinogenesis--a health risk assessment and management approach" (PDF) . Mol. Cell. Biochem. 255 (1–2): 47–55. doi :10.1023/B:MCBI.0000007260.32981.b9 . PMID 14971645 .
^ Hartwig A, Groblinghoff UD, Beyersmann D, Natarajan AT, Filon R, Mullenders LH (February 1997). "Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts" . Carcinogenesis 18 2 ): 399–405. doi :10.1093/carcin/18.2.399 PMID 9054635 .
^ Kachinskas DJ, Phillips MA, Qin Q, Stokes JD, Rice RH (November 1994). "Arsenate perturbation of human keratinocyte differentiation" . Cell Growth Differ. 5 11 ): 1235–41. PMID 7848924 . Archived from the original on 2013-02-23. Retrieved 2009-02-09 .
^ Germolec DR, Yoshida T, Gaido K, et al. (November 1996). "Arsenic induces overexpression of growth factors in human keratinocytes". Toxicol. Appl. Pharmacol. 141 (1 ): 308–18. doi :10.1006/taap.1996.0288 . PMID 8917704 .
^ Son SB, Song HJ, Son SW (March 2008). "Successful treatment of palmoplantar arsenical keratosis with a combination of keratolytics and low-dose acitretin" . Clin. Exp. Dermatol. 33 2 ): 202–4. doi :10.1111/j.1365-2230.2007.02596.x . PMID 18039342 . Archived from the original on 2013-01-05.
^ a b Khandpur S, Sharma VK (October 2003). "Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil" . J. Dermatol. 30 10 ): 730–4. doi :10.1111/j.1346-8138.2003.tb00468.x . PMID 14684956 . Archived from the original on 2011-07-22.
^ Sharma SC, Simpson NB (1983). "Treatment of arsenical keratosis with etretinate". Acta Derm. Venereol. 63 5 ): 449–52. PMID 6197851 .
^ Boonchai W (April 2006). "Treatment of precancerous and cancerous lesions of chronic arsenicism with 5% imiquimod cream". Arch Dermatol 142 (4 ): 531–2. doi :10.1001/archderm.142.4.531 . PMID 16618886 .
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Arsenical_keratosis&oldid=1187146855 " C a t e g o r i e s : ● E p i d e r m a l n e v i , n e o p l a s m s , a n d c y s t s ● A r s e n i c H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a
● T h i s p a g e w a s l a s t e d i t e d o n 2 7 N o v e m b e r 2 0 2 3 , a t 1 9 : 3 1 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
