If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.[1][2]
Inrats, the exposure of subterminal galactoseorGalNAc residues may assist in receptor-mediated endocytosis of asialoglycoproteins by asialoglycoprotein receptorsonKuppfer cells. The human ortholog of this gene is non-functional, but hepatocyte asialoglycoprotein receptors are functional in both humans and rats.[3]
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