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Contents

   



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1 See also  




2 References  













BD1031






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From Wikipedia, the free encyclopedia
  
(Redirected from BD-1031)
BD1031
Identifiers

  • (R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine

CAS Number
ChemSpider
Chemical and physical data
FormulaC15H20Cl2N2
Molar mass299.24 g·mol−1
3D model (JSmol)

  • c1cc(c(cc1CCN2CCN3CCC[C@@H]3C2)Cl)Cl

  • InChI=1S/C15H20Cl2N2/c16-14-4-3-12(10-15(14)17)5-7-18-8-9-19-6-1-2-13(19)11-18/h3-4,10,13H,1-2,5-9,11H2/t13-/m1/s1

  • Key:IGVDQXLOMXGWKN-CYBMUJFWSA-N

BD1031or(R)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor agonist, with a reported binding affinityofKi = 1 ± 0.2 nM for the sigma-1 receptor and 80 times selectivity over the sigma-2 receptor.[1] The enantiomer of BD1031 is known as BD1018.

Consistent with other reported sigma receptor agonists, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice.[1]

See also[edit]

References[edit]

  1. ^ a b Matsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD (2001). "Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice". Eur. J. Pharmacol. 419 (2–3): 163–74. doi:10.1016/s0014-2999(01)00968-2. PMID 11426838.

Retrieved from "https://en.wikipedia.org/w/index.php?title=BD1031&oldid=1213043913"
Categories: 
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 ●Phenethylamines
 ●Chloroarenes
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