BCAM | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | BCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group) | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 612773; MGI: 1929940; HomoloGene: 21149; GeneCards: BCAM; OMA:BCAM - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene.[5] BCAM has also recently been designated CD239 (cluster of differentiation 239).
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.[5]
BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasisofovarian cancer.[6][7][8]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |