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| Beta-globin co-transcriptional cleavage ribozyme | |
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Predicted secondary structure and sequence conservation of CoTC_ribozyme
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| Identifiers | |
| Symbol | CoTC_ribozyme |
| Rfam | RF00621 |
| Other data | |
| RNA type | Gene; ribozyme |
| Domain(s) | Eukaryota |
| SO | SO:0000374 |
| PDB structures | PDBe |
The Beta-globin co-transcriptional cleavage ribozyme (CotC ribozyme) was proposed to be an RNA enzyme known as a ribozyme.
Transcription termination of RNA polymerase II transcripts is proposed to occur by a two-stage process.[1] The first stage involves pre-termination cleavage (PTC) of the nascent transcript downstream of the poly(A) site. This process is also referred to as co-transcriptional cleavage (CoTC). The CoTC process in the human beta-globin gene was proposed to involve an RNA self-cleaving activity located in the 3' flanking region of the beta-globin gene. The CoTC core is highly conserved in the 3' UTR of other primate beta-globin genes.[2]
However, there has been no independent confirmation of these findings, and a subsequent analysis by a team including members of the original report failed to demonstrate ribozyme activity.[3]
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