Little was born in Glens Falls on September 28, 1940.[2] Little is a graduate of the College of Saint Rose with a degree in Elementary Education.[3] She has worked as both teacher and a realtor.[4]
Little has six children and seventeen grandchildren.[5] She is divorced.[6]
Little first entered public service as a member and later Chair of the Town of Queensbury Recreation Commission.[6] In 1986 she was elected to serve as an At-Large Supervisor to the Warren County Board of Supervisors for the Town of Queensbury, where she served on numerous boards and committees and as County Budget Officer in 1990 and 1991.[7]
In 1995, Little won a special election to serve in the New York State Assembly, and would serve in the Assembly until winning election to the Senate in 2002.[8]
In 2002, incumbent Republican Senator Ronald B. Stafford decided not to seek another term.[9] As a result, Little announced that she would run to replace him.[10] Despite the district being competitive on paper, Little easily won election to her first term in the Senate against Democrat Boyce Sherwin, 77% to 23%.[11]
Since her initial election, Little has never faced serious opposition, and was unopposed in 2004, 2008, 2010, 2012 and 2014.[12] She faced the closest election of her career in 2018, but still won 64% to 36%.[13]
Before the Republicans lost the Senate majority in the 2018 elections, Little served as Chair of the Housing, Construction and Community Development Committee.[5]
In December 2019, Little announced that she would not seek re-election the following year.[16]
Little voted "No" on same-sex marriage legislation in December 2009 and the bill received no Republican Senate support.[18] Little has said she supports civil unions. In 2011, Little voted against the Marriage Equality Act, which the Senate passed 33-29.[19] The 2011 bill became law.[20]