Powell entered the Florida football program out of Deerfield Beach High School as a four-star recruit and was ranked 267th overall in the ESPN 300 and was also the 34th ranked athlete in the 2014 recruiting class. Brandon began his collegiate career as a running backatFlorida. He later switched to wide receiver his sophomore year. During his freshman season, he caught 15 passes for 147 yards with a touchdown. As a sophomore, Powell caught 29 passes for 390 yards and three touchdowns, including a career long 77 yard score against Ole Miss. As a junior, he had 45 receptions for 387 yards and 2 touchdowns. During his senior year, Powell had a team high 42 receptions for 406 yards and 3 touchdowns.[1]
Powell signed for the Detroit Lions as an undrafted free agent on May 11, 2018.[3] On December 30, Powell started in place of Kenny Golladay and caught six passes for 103 yards against the Green Bay Packers.[4]
On August 31, 2019, Powell was waived by the Lions.[5]
On September 2, 2019, Powell was signed to the practice squad of the Atlanta Falcons.[6] On November 5, 2019, Powell was promoted to the active roster.[7]
On November 4, 2021, Powell was signed to the Los Angeles Rams practice squad.[11] On December 26, 2021, in a game against the Minnesota Vikings, Powell returned a punt 61 yards for a touchdown that was key in the Rams' victory, ensuring a playoff berth for the team. He was named National Football Conference Special Teams Player of the Week for the first time in his NFL career for his performance.[12][13] Powell won Super Bowl LVI against the Cincinnati Bengals.[14]
On March 19, 2022, Powell re-signed with the Rams on a one-year deal.[15]
On March 22, 2023, Powell signed with the Vikings.[16] He served as the team's primary punt returner in 2023 and also put up career receiving numbers with 29 catches for 324 yards and one touchdown.
On March 12, 2024, Powell signed a one-year contract extension with the Vikings.[17]
