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This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "Butamben" – news · newspapers · books · scholar · JSTOR (May 2015)
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Other names | n-butyl p-aminobenzoate |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration | Topical |
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ECHA InfoCard | 100.002.107 ![]() |
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Formula | C11H15NO2 |
Molar mass | 193.246 g·mol−1 |
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Melting point | 58 °C (136 °F) |
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Butamben is a local anesthetic. Proprietary names includes Alvogil in Spain and Alvogyl in Switzerland. It is one of three components in the topical anesthetic Cetacaine.
It is the esterof4-aminobenzoic acid and butanol.[1] A white, odourless, crystalline powder. that is mildly soluble in water (1 part in 7000) and soluble in alcohol, ether, chloroform, fixed oils, and dilute acids. It slowly hydrolyses when boiled with water. Synonyms include Butamben, Butilaminobenzoato, and Butoforme.
The esterification between 4-Nitrobenzoic acid [62-23-7] (1) and 1-Butanol [71-36-3] (2) gives Butyl 4-Nitrobenzoate [120-48-9] (3). Bechamp reduction then gives Butamben (4).
Alternatively, 4-aminobenzoic acid can be used directly.
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