Jump to content
 







Main menu
   


Navigation  



Main page
Contents
Current events
Random article
About Wikipedia
Contact us
Donate
 




Contribute  



Help
Learn to edit
Community portal
Recent changes
Upload file
 








Search  

































Create account

Log in
 









Create account
 Log in
 




Pages for logged out editors learn more  



Contributions
Talk
 



















Contents

   



(Top)
 


1 References  



1.1  Other  
















rs1800955







Add links
 









Article
Talk
 

















Read
Edit
View history
 








Tools
   


Actions  



Read
Edit
View history
 




General  



What links here
Related changes
Upload file
Special pages
Permanent link
Page information
Cite this page
Get shortened URL
Download QR code
Wikidata item
 




Print/export  



Download as PDF
Printable version
 
















Appearance
   

 






From Wikipedia, the free encyclopedia
 

(Redirected from C-521T)

SNP: rs1800955
Name(s)C-521T, -521C/T
GeneDRD4
Chromosome11
RegionPromoter
External databases
EnsemblHuman SNPView
dbSNP1800955
HapMap1800955
SNPedia1800955
ALFREDSI000215I
SzGeneMeta-analysis
Overview

Ingenetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP). It is located in the promoter region of the DRD4 gene. This gene codes for the dopamine receptor D4.

Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder.[1]

The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory.[2][3] A 2008 meta-analysis indicates a possible association between novelty seeking and C-521T though rather small.[4]

References[edit]

  1. ^ "Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs1800955". Schizophrenia Research Forum. Retrieved 2008-09-05.[permanent dead link]
  • ^ Y. Okuyama, H. Ishiguro, M. Nankai, H. Shibuya, A. Watanabe & T. Arinami (January 2000). "Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait". Molecular Psychiatry. 5 (1): 64–69. doi:10.1038/sj.mp.4000563. PMID 10673770.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • ^ Z. Ronai, A. Szekely, Z. Nemoda, K. Lakatos, J. Gervai, M. Staub & M. Sasvari-Szekely (January 2001). "Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene". Molecular Psychiatry. 6 (1): 35–38. doi:10.1038/sj.mp.4000832. PMID 11244482.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • ^ Marcus R. Munafo, Binnaz Yalcin, Saffron A. Willis-Owen & Jonathan Flint (January 2008). "Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data". Biological Psychiatry. 63 (2): 197–206. doi:10.1016/j.biopsych.2007.04.006. PMID 17574217. S2CID 28997438.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Other[edit]


  • t
  • e

  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Rs1800955&oldid=1212911765"

    Categories: 
    SNPs on chromosome 11
    Human chromosome 11 gene stubs
    Hidden categories: 
    All articles with dead external links
    Articles with dead external links from March 2024
    Articles with permanently dead external links
    CS1 maint: multiple names: authors list
    All stub articles
     



    This page was last edited on 10 March 2024, at 04:36 (UTC).

    Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.



    Privacy policy

    About Wikipedia

    Disclaimers

    Contact Wikipedia

    Code of Conduct

    Developers

    Statistics

    Cookie statement

    Mobile view



    Wikimedia Foundation
    Powered by MediaWiki