Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.[5][6]
Cell adhesion molecule 1 has been shown to interact with EPB41L3.[7]
Genome-wide association studies identified an association between body mass index and two loci near the CADM1 and CADM2 gene.[8] Experimental results of another study showed that obese mice had an over expression of both CADM1 and CADM2 genes, and that loss of CADM1 protected mice from obesity, promoting a negative energy balance and weight loss.[9] Furthermore, a 2019 GWAS study revealed an association between Anorexia nervosa and CADM1.[10] In the brain, this genes mediate synaptic assembly, and mutations in CADM1 are also associated with Autistic spectrum disorder. [11]
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| Calcium-independent |
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| Calcium-dependent |
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| Other |
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