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(Top) 1 References 2 External links 3 Further reading

CCNL1

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CCNL1

Identifiers

Aliases

CCNL1, ANIA6A, PRO1073, ania-6a, BM-001, cyclin L1

External IDs

OMIM: 613384; MGI: 1922664; HomoloGene: 10541; GeneCards: CCNL1; OMA:CCNL1 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q25.31	Start	157,146,508 bp^[1]
Band	3q25.31	End	157,160,760 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 E1	Start	65,853,572 bp^[2]
Band	3\|3 E1	End	65,865,670 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastric mucosa

granulocyte

left uterine tube

monocyte

left ovary

right ovary

right lung

skin of abdomen

left lobe of thyroid gland

anterior pituitary

Top expressed in

granulocyte

saccule

Rostral migratory stream

tail of embryo

crypt of lieberkuhn of small intestine

pineal gland

otic vesicle

thymus

otic placode

genital tubercle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity protein binding
Cellular component	nuclear speck cyclin-dependent protein kinase holoenzyme complex nucleoplasm nucleus
Biological process	positive regulation of phosphorylation of RNA polymerase II C-terminal domain RNA processing regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57018


56706

Ensembl


ENSG00000163660


ENSMUSG00000027829

UniProt


Q9UK58


Q52KE7

RefSeq (mRNA)


NM_001308185 NM_020307


NM_001025442 NM_001025443 NM_019937 NM_001355432 NM_001355433

RefSeq (protein)


NP_001295114 NP_064703


NP_064321 NP_001342361 NP_001342362

Location (UCSC)

Chr 3: 157.15 – 157.16 Mb

Chr 3: 65.85 – 65.87 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163660 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027829 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (Jul 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". J Biol Chem. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.

^ "Entrez Gene: CCNL1 cyclin L1".

External links[edit]

Human CCNL1 genome location and CCNL1 gene details page in the UCSC Genome Browser.

Further reading[edit]

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

Berke JD, Sgambato V, Zhu PP, et al. (2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997. S2CID 14486999.

Redon R, Hussenet T, Bour G, et al. (2002). "Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer". Cancer Res. 62 (21): 6211–7. PMID 12414649.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Sticht C, Hofele C, Flechtenmacher C, et al. (2005). "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)". Br. J. Cancer. 92 (4): 770–4. doi:10.1038/sj.bjc.6602400. PMC 2361871. PMID 15700036.

Muller D, Millon R, Théobald S, et al. (2006). "Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma". Br. J. Cancer. 94 (7): 1041–4. doi:10.1038/sj.bjc.6603036. PMC 2361229. PMID 16598186.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

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