CD96 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CD96, TACTILE, CD96 molecule | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606037; MGI: 1934368; HomoloGene: 68489; GeneCards: CD96; OMA:CD96 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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CD96 (Cluster of Differentiation96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene.[5] CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1).[6] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation[citation needed]. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligandisCD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.[7]
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.