CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1.[5][6][7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.[8]
CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle.[9] Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1[10] - for ubiquitin-mediated protein degradation.[11] CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[7]
CDC34 has been shown to interact with CSNK2B,[12] BTRC[13][14] and CDK9.[15]
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| Chaperones/ protein folding |
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| Protein targeting |
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| Ubiquitin (ubiquitylation) |
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| Ubiquitin-like proteins (UBL) |
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