Contents

CENPH

Protein-coding gene in the species Homo sapiens

CENPH
Identifiers
Aliases	CENPH, centromere protein H
External IDs	OMIM: 605607; MGI: 1349448; HomoloGene: 32519; GeneCards: CENPH; OMA:CENPH - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 69,189,574 bp[1] End 69,210,357 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 53.23 cM|13 D1 Start 100,759,674 bp[2] End 100,775,899 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone ganglionic eminence oocyte right testis testicle left testis secondary oocyte bone marrow Achilles tendon Top expressed in zygote yolk sac tail of embryo secondary oocyte genital tubercle embryo epiblast embryo abdominal wall mandibular prominence More reference expression data BioGPS n/a
Gene ontology Molecular function kinetochore binding protein binding Cellular component chromosome cytosol chromosome, centromeric region nucleus kinetochore nucleoplasm nucleolus Biological process kinetochore assembly kinetochore organization CENP-A containing chromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64946 26886 Ensembl ENSG00000153044 ENSMUSG00000045273 UniProt Q9H3R5 Q9QYM8 RefSeq (mRNA) NM_022909 NM_021886 RefSeq (protein) NP_075060 NP_068686 NP_001386457 Location (UCSC) Chr 5: 69.19 – 69.21 Mb Chr 13: 100.76 – 100.78 Mb PubMed search [3] [4]
Wikidata
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Centromere protein H is a protein that in humans is encoded by the CENPH gene.^[5][6][7] It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.^[8][9]

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. CENP-H is required for the localisation of CENP-C, but not CENP-A, to the centromere. However, it may be involved in the incorporation of newly synthesised CENP-A into centromeres via its interaction with the CENP-A/CENP-HI complex.^[10] CENP-H localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.^[11] CENP-H contains a coiled-coil structure and a nuclear localisation signal.^[11]

Studies show that CENP-H may be associated with certain human cancers.^[12][13]

CENP-H shows sequence similarity to the Schizosaccharomyces pombe kinetochore protein Fta3 which is a subunit of the Sim4 complex. This complex is required for loading the DASH complex onto the kinetochore via interaction with dad1. Fta2, Fta3 and Fta4 associate with the central core and inner repeat region of the centromere.^[14]

CENPH has also been shown to interact with KIAA0090.^[15] The significance of this interaction is unclear.

• Human CENPH genome location and CENPH gene details page in the UCSC Genome Browser.
• Human PMF1 genome location and PMF1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.