Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 Interactions 2 References 3 External links 4 Further reading

CENPK

●العربية ●Español ●مصرى ●Татарча / tatarça ●Українська Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

CENPK

Identifiers

Aliases

CENPK, AF5alpha, CENP-K, P33, Solt, FKSG14, centromere protein K

External IDs

OMIM: 611502; MGI: 1926210; HomoloGene: 11035; GeneCards: CENPK; OMA:CENPK - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q12.3	Start	65,517,766 bp^[1]
Band	5q12.3	End	65,563,168 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 D1	Start	104,365,119 bp^[2]
Band	13\|13 D1	End	104,388,900 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

ventricular zone

testicle

secondary oocyte

gonad

ganglionic eminence

thymus

rectum

appendix

bone marrow

Top expressed in

fetal liver hematopoietic progenitor cell

medial ganglionic eminence

primitive streak

genital tubercle

vas deferens

spermatid

otic placode

Paneth cell

embryo

maxillary prominence

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding
Cellular component	cytosol nucleus nucleoplasm chromosome, centromeric region chromosome kinetochore
Biological process	CENP-A containing chromatin assembly kinetochore assembly mitotic sister chromatid segregation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64105


60411

Ensembl


ENSG00000123219


ENSMUSG00000021714

UniProt


Q9BS16


Q9ESN5

RefSeq (mRNA)


NM_001267038 NM_022145 NM_001349367 NM_001349368 NM_001349369


NM_021790 NM_181061 NM_001377093 NM_001377094 NM_001377095

RefSeq (protein)


NP_001253967 NP_071428 NP_001336296 NP_001336297 NP_001336298


NP_068562 NP_851406 NP_001364022 NP_001364023 NP_001364024

Location (UCSC)

Chr 5: 65.52 – 65.56 Mb

Chr 13: 104.37 – 104.39 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centromere protein K is a protein that in humans is encoded by the CENPK gene.^[5]^[6]

Interactions[edit]

CENPK has been shown to interact with SOX6.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123219 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021714 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia". Oncogene. 13 (10): 2121–30. PMID 8950979.

^ "Entrez Gene: CENPK centromere protein K".

^ Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

External links[edit]

Human CENPK genome location and CENPK gene details page in the UCSC Genome Browser.

Further reading[edit]

Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (Jun 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.

Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.

Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.

Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.

Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=CENPK&oldid=1170094264" Categories: ●Genes on human chromosome 5 ●Human chromosome 5 gene stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●All stub articles ●This page was last edited on 13 August 2023, at 04:33 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view