Crk-like protein is a protein that in humans is encoded by the CRKL gene.[5][6]
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.[7]
CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.[8][9]
CRKL has been shown to interact with:
PDB gallery
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2bzx: ATOMIC MODEL OF CRKL-SH3C MONOMER
2bzy: DIMERIC OF CRKL-SH3C DOMAIN
2dbk: Solution structures of the SH3 domain of human Crk-like protein
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