In 2011, d'Arnaud was playing for the Indianapolis Indians when he was called up to the majors by the Pittsburgh Pirates for the first time on June 24.[2] In his major league debut, he recorded his first major league hit, a triple, off Boston Red Sox pitcher Jon Lester. D'Arnaud appeared in 48 games for the Pirates in 2011, batting .217, with six runs batted in and 12 stolen bases.[3]
In 2012, d'Arnaud played 98 games for Indianapolis, batting .252 with 34 stolen bases. He was recalled by the Pirates on September 10, 2012. He played eight games for the Pirates in 2012, scoring a pair of runs and getting a stolen base.[4]
On March 20, 2013, the Pirates placed d'Arnaud on the 60-day disabled list after surgery to repair a partially torn ligament in his left thumb.[5] D'Arnaud started a rehab assignment with the Bradenton Marauders on May 16.[6] On May 18, his rehab assignment was transferred to the Altoona Curve, and then to the Indianapolis Indians on May 25. He was activated from the disabled list and optioned to Indianapolis on May 31, where he played the rest of the season.
D'Arnaud was designated for assignment on February 24, 2014 when Brent Morel was claimed on waivers from the Toronto Blue Jays.[7] He spent the season with Indianapolis, and his contract was selected by the Pirates on September 2 after the rosters expanded. He appeared in eight games for the Pirates in 2014, and was used as a pinch runner and defensive replacement.
On November 3, he was outrighted to Indianapolis and elected free agency.
On November 13, 2014 d'Arnaud signed a minor league deal with the Philadelphia Phillies.[8] He spent the 2015 minor league season with the Triple-A Lehigh Valley IronPigs. His contract was selected by the Phillies from Lehigh Valley on September 14, 2015.
D'Arnaud signed a minor league contract with the San Francisco Giants on January 4, 2018.[14] His contract was selected from the Triple–A Sacramento River Cats on July 7. In 42 games for San Francisco, d'Arnaud hit .215/.253/.366 with three home runs and nine RBI. On October 23, he was removed from the 40–man roster and sent outright to Sacramento.[15]
On December 17, 2018, d'Arnaud signed a minor league contract with the Texas Rangers.[16] He was assigned to the Triple-ANashville Sounds to open the 2019 season.[17] He was released on June 18.[18]
On June 21, 2019, d’Arnaud signed a minor league deal with the Kansas City Royals. He became a free agent following the 2019 season.[19]
On February 17, 2020, d’Arnaud announced his retirement from baseball via Instagram.[citation needed]
However, the retirement was short-lived as he made himself available to play for the Philippines in the 2021 World Baseball Classic qualifiers to be held in Tucson, Arizona from March 20 to 25, 2020. D'Arnaud is Filipino from his mother Marita's side of the family.[20]
D'Arnaud and his wife, Kaitlyn, married in 2016.[22] They have three sons together.[23]
D'Arnaud is also known for his musical pursuits, and is the lead singer of the Chase d'Arnaud Band.[24] In 2016, they performed at Bonnaroo Music Festival.[25]