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( T o p )
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A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Education
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Vakoc graduated with a degree in Biochemistry from Pennsylvania State University in 2001.[1] M.D. and his Ph.D. from the University of Pennsylvania . His PhD research was performed with Gerd Blobel on the regulation of gene expression during hematopoiesis .[1] Cold Spring Harbor Laboratory .[1] [2]
Career and research
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Vakoc uses CRISPR/Cas9 technology to probe the epigenetic regulation of cancer and to identify new cancer drug targets .[1] [2] BRD4 was particularly important for leukemia , leading to a series of clinical trials with a new drug, JQ1 .[3] [4] [5] epigenetics , Vakoc has also identified a new subtype of lung cancer [6] metastasis in pancreatic cancer .[7] [8]
Recently, Vakoc has developed a CRISPR screening approach to identify the protein domains that are most important for cancer growth.[9] [10]
Awards and honors
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References
[ edit ]
^ "A Conversation with Christopher Vakoc" . Cold Spring Harbor Symposia on Quantitative Biology . 81 doi :10.1101/sqb.2016.81.031617 ISSN 0091-7451 . PMID 28123048 .
^ Zuber, Johannes; Shi, Junwei; Wang, Eric; Rappaport, Amy R.; Herrmann, Harald; Sison, Edward A.; Magoon, Daniel; Qi, Jun; Blatt, Katharina; Wunderlich, Mark; Taylor, Meredith J. (October 2011). "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia" . Nature . 478 (7370): 524–528. Bibcode :2011Natur.478..524Z . doi :10.1038/nature10334 . ISSN 1476-4687 . PMC 3328300 PMID 21814200 .
^ Ricks, Delthia (2015-04-18). "Cold Spring Harbor researchers test treatment that can halt acute myeloid leukemia" . Newsday . Retrieved 2020-05-01 .
^ Ricks, Delthia (2018-07-14). "Cold Spring Harbor scientists discover new form of lung cancer" . Newsday . Retrieved 2020-05-01 .
^ Kwon, Diana (2017-07-27). "Enhancers Drive Pancreatic Cancer Metastasis: Study" . The Scientist . Retrieved 2020-05-01 .
^ "LI scientists make key pancreatic cancer find" . Newsday . Retrieved 2020-05-04 .
^ Rood, Jenny (2015-05-13). "Targeting Protein Domains with CRISPR" . The Scientist . Retrieved 2020-05-01 .
^ Howley, Elaine K. (2018-09-12). "What's the likelihood that CRISPR will cure Cancer?" . U.S. News & World Report . Archived from the original on 2018-09-13.
^ "AACR recognizes outstanding cancer research achievements of Dr. Christopher Vakoc" . EurekAlert! . Retrieved 2020-05-04 .
^ Grisham, Julie (2019-11-08). "Three Scientists are Named Winners of the Paul Marks Prize for Cancer Research" . Memorial Sloan Kettering Cancer Center. Retrieved 2020-05-03 .
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Christopher_Vakoc&oldid=1227773199 " C a t e g o r i e s : ● L i v i n g p e o p l e ● M o l e c u l a r b i o l o g i s t s ● E b e r l y C o l l e g e o f S c i e n c e a l u m n i ● U n i v e r s i t y o f P e n n s y l v a n i a a l u m n i H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● Y e a r o f b i r t h m i s s i n g ( l i v i n g p e o p l e )
● T h i s p a g e w a s l a s t e d i t e d o n 7 J u n e 2 0 2 4 , a t 1 8 : 3 0 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
